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Your Brain Uses the Same Circuits for Physical and Social Pain

Curated by Surfaced Editorial·Regularly updated

A brain scan with the same region glowing red in two side-by-side images: one labeled 'Stubbed Toe' and the other 'Social Rejection'

Neuroimaging studies show that social rejection activates the anterior cingulate cortex and insula — the same brain regions that process physical pain. This is why heartbreak and exclusion literally hurt.

Why It’s Interesting

It means social pain is not metaphorical — it is neurologically real. Studies have shown that taking acetaminophen (Tylenol) can actually reduce the sting of social rejection, because the brain genuinely processes both types of pain through overlapping pathways.

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